Therapeutic Indications
Uses
Acute treatment of migraine attacks with or without aura
Dosage
50mg to 100mg at onset of attack.
If the patient has responded to first dose and symptoms recur, a second dose may be given provided that there is a minimum interval of 2 hours between doses.
Maximum dose 300mg in any 24 hour period.
Sumatriptan should be given as a single dose and may be repeated once after at least 2 hours if migraine recurs.
Children aged 12 to 18 years (unlicensed):
50mg to 100mg at onset of migraine.
Children aged 10 to 12 years (unlicensed):
50mg at onset of migraine.
Children aged 6 to 10 years (unlicensed):
25mg at onset of migraine.
Contraindications
Children under 6 years
Suspected ischaemic heart disease
Within 2 weeks of discontinuing MAOIs
Coronary vasospasm
History of cerebrovascular accident
History of myocardial infarction
History of transient ischaemic attack
Ischaemic heart disease
Moderate hypertension
Peripheral vascular disease
Prinzmetal's angina
Severe hepatic impairment
Uncontrolled hypertension
Precautions and Warnings
Children aged 6 to 18 years
Patients over 65 years
Predisposition to ischaemic heart disease
Breastfeeding
Cardiac arrhythmias
Galactosaemia
Glucose-galactose malabsorption syndrome
Hepatic impairment
History of seizures
Hypertension
Lactose intolerance
Pregnancy
Reduced seizure threshold
Renal impairment
Pregnancy and Lactation
Pregnancy
Use Sumatriptan with caution in pregnancy.
Lactation
Use sumatriptan with caution in breastfeeding.
Side Effects
Altered liver function tests
Anaphylaxis
Angina
Anxiety
Arrhythmias
Arthralgia
Bradycardia
Cerebrovascular disorders
Coronary vasospasm
Diarrhoea
Diplopia
Dizziness
Drowsiness
Dyspnoea
Dystonia
Eye flickering
Fatigue
Flushing
Hyperhidrosis
Hypersensitivity reactions
Hypoaesthesia
Hypotension
Impaired vision
Increased blood pressure (transient)
Ischaemic colitis
Loss of vision
Myalgia
Myocardial infarction
Nausea
Neck stiffness
Nystagmus
Pain
Palpitations
Paraesthesia
Raynaud's phenomenon
Scotoma
Seizures
Sensation of cold
Sensation of heat
Sensation of heaviness
Sensation of pressure
Sensation of tightness
Sensory disturbances
Serotonin syndrome
Somnolence
Tachycardia
Tingling sensation
Transient ischaemic ECG changes
Tremor
Vomiting
Weakness