

Peridex, PerioGard: PO rinse 15 mL q12hr
PerioChip: 1-8 chips in periodontal pocket, depth >5 mm; repeat q3Months
Amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy
Safety and efficacy not established
Hypersensitivity
Serious allergic reactions reported, including anaphylaxis that can occur within minutes presenting as wheezing, difficulty breathing, facial edema, hives, severe rash, or hypotension and shock
Extended-release pellets: Anaphylaxis and serious allergic reactions reported during postmarketing surveillance
Increase of tartar on teeth
Changes in taste
Staining of oral surfaces (mucosa, teeth, dorsum of tongue) may be visible as soon as 1wk after therapy begins and is more pronounced when there is a heavy accumulation of unremoved plaque and when teeth fillings have rough surfaces; stain does not have a clinically adverse effect but because removal may not be possible, patient with frontal restoration should be advised of the potential permanency of the stain
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.