Relief of pain and inflammation in rheumatic diseases (unlicensed)

Contraindications

Asthma, urticaria or acute rhinitis associated with NSAIDS
History of gastrointestinal haemorrhage
History of gastrointestinal perforation
History of peptic ulcer
Nasal polyps, angioedema, and bronchospastic reactivity to NSAIDs
Peptic ulcer
Severe cardiac failure
Severe hepatic impairment
Severe renal impairment
Third trimester of pregnancy

Precautions and Warnings

Children under 18 years
Elderly
Females attempting to conceive
Predisposition to fluid retention
Risk factors for cardiovascular disorder
Sepsis
Systemic infection
Asthma
Breastfeeding
Cardiac failure
Cerebrovascular disorder
Coagulopathy
Connective tissue disorder
Crohn's disease
Diabetes mellitus
Epileptic disorder
First trimester of pregnancy
Galactosaemia
Gastrointestinal diverticula
Glucose-galactose malabsorption syndrome
Haematological disorder
Hepatic impairment
History of asthma
History of gastrointestinal disorder
Hypertension
Hypovolaemia
Ischaemic heart disease
Lactose intolerance
Parkinsonism
Peripheral arterial circulatory disorder
Psychiatric disorder
Renal impairment
Second trimester of pregnancy
Systemic lupus erythematosus
Ulcerative colitis

Pregnancy and Lactation

Pregnancy

Indometacin is contraindicated during the 3rd trimester of pregnancy. Use with caution during the 1st and 2nd trimester.

Lactation

Use indometacin with caution during breastfeeding.

Side Effects

Aggravation of existing asthma
Altered liver function tests
Anaemia
Anaphylaxis
Angioedema
Anorexia
Anxiety
Arrhythmias
Arterial thrombosis
Aseptic meningitis
Asthma
Blood dyscrasias
Blood urea increased
Bone marrow depression
Breast changes
Bronchospasm
Bullous dermatoses
Cerebral oedema
Chest pain
Cholestasis
Coma
Confusion
Congestive cardiac failure
Convulsions
Depersonalisation
Depression
Disorientation
Dizziness
Drowsiness
Dysarthria
Dyspnoea
Ecchymosis
Epistaxis
Erythema multiforme
Erythema nodosum
Exacerbation of Crohn's disease
Exacerbation of epilepsy
Exacerbation of psoriasis
Eye disorder
Fatigue
Fever
Flushing
Gastro-intestinal symptoms
Gastro-intestinal ulceration and bleeding
Glycosuria
Haematuria
Hair loss
Hallucinations
Headache
Hearing disturbances
Hepatitis
Hyperglycaemia
Hyperkalaemia
Hypersensitivity reactions
Hypertension
Hypotension
Ileitis
Increase in serum ALT/AST
Insomnia
Interstitial nephritis
Intravascular coagulation (disseminated)
Involuntary movement disorders
Jaundice
Light-headedness
Listlessness
Malaise
Muscle weakness
Neck stiffness
Nephrotic syndrome
Nervousness
Non-specific allergic reactions
Oedema
Palpitations
Pancreatitis
Paraesthesia
Parkinsonism
Peptic ulceration with perforation and haemorrhage
Peripheral neuropathy
Petechiae
Photosensitivity
Proteinuria
Psychiatric disorders
Pulmonary eosinophilia
Purpura
Renal failure
Renal impairment
Skin disorder
Stevens-Johnson syndrome
Stomatitis
Sweating
Syncope
Tachycardia
Tinnitus
Toxic epidermal necrolysis
Ulcerative colitis
Vaginal bleeding
Vasculitis
Vertigo