Drugs List

• mefenamic acid 250mg capsules
• mefenamic acid 500mg tablets
• mefenamic acid 50mg/5ml suspension
  
  

  Therapeutic Indications

  Uses

  Dysmenorrhoea
  Menorrhagia
  Osteoarthritis
  Pain - mild to moderate
  Pyrexia in children
  Relief of headache
  Rheumatoid arthritis
  Still's disease (juvenile arthritis)

  Anti-inflammatory analgesic for the symptomatic relief of:
  Rheumatoid arthritis (including Still's disease);
  Osteoarthritis;
  Pain including muscular, traumatic, dental, postoperative and post-partum;
  Headache.

  Primary dysmenorrhoea.

  Pyrexia in children.

  Menorrhagia due to dysfunction and presence of an IUD when other pelvic pathology has been ruled out.

  The recommended dose is 500 mg three times daily.

  In menorrhagia to be administered on the first day of excessive bleeding and continued according to the judgement of the physician.

  In dysmenorrhoea to be administered at the onset of menstrual pain and continued according to the judgement of the physician.

  
  

  Contraindications

  Children under 6 months
  Coronary artery bypass graft
  Breastfeeding
  Galactosaemia
  Gastrointestinal haemorrhage
  Gastrointestinal ulcer
  History of gastrointestinal haemorrhage
  History of gastrointestinal perforation
  History of gastrointestinal ulceration
  History of peptic ulcer
  Inflammatory bowel disease
  Peptic ulcer
  Severe cardiac failure
  Severe hepatic impairment
  Severe renal impairment
  Third trimester of pregnancy

  Precautions and Warnings

  Elderly
  Haemorrhagic diathesis
  Risk factors for cardiovascular disorder
  Asthma
  Cardiac failure
  Cardiac impairment
  Cerebrovascular disorder
  Connective tissue disorder
  Crohn's disease
  Dehydration
  Diabetes mellitus
  Epileptic disorder
  First trimester of pregnancy
  Glucose-galactose malabsorption syndrome
  Hepatic impairment
  History of asthma
  Hypertension
  Intracranial haemorrhage
  Ischaemic heart disease
  Lactose intolerance
  Peripheral arterial circulatory disorder
  Porphyria
  Renal impairment
  Respiratory impairment
  Second trimester of pregnancy
  Systemic lupus erythematosus
  Ulcerative colitis

  Pregnancy and Lactation

  Pregnancy

  Mefenamic acid is contraindicated in the third trimester of pregnancy

  Lactation

  Mefenamic acid is contraindicated in breastfeeding.

• Side Effects

  Abnormal liver function tests
  Aggravation of existing asthma
  Agranulocytosis
  Allergic reaction
  Anaemia
  Anaphylaxis
  Angioedema
  Anorexia
  Aplastic anaemia
  Arterial thrombosis
  Aseptic meningitis
  Asthma
  Bone marrow hypoplasia
  Bronchospasm
  Bullous dermatoses
  Cardiac failure
  Cholestatic jaundice
  Colitis
  Confusion
  Convulsions
  Decrease in haematocrit
  Dehydration
  Depression
  Diarrhoea
  Disorientation

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