

Prophylaxis of chronic stable angina pectoris
Treatment of essential hypertension
Children under 18 years
Aortic stenosis
Breastfeeding
Cardiogenic shock
Decompensated cardiac failure
Haemodynamically significant valvular heart disease
Left ventricular outflow obstruction
Pregnancy
Unstable angina
Within 1 month of a myocardial infarction
Elderly
Galactosaemia
Glucose-galactose malabsorption syndrome
Hepatic impairment
Lactose intolerance
Severe left ventricular failure
Tachycardia
Not suitable for secondary prevention of myocardial infarction
Reduce dose in patients with hepatic impairment
Advise ability to drive/operate machinery may be affected by side effects
Some formulations contain castor oil polyoxyl which may cause diarrhoea
Some formulations contain lactose
Some formulations contain propylene glycol
Increased risk of hypotension with diuretics and other antihypertensives
Discontinue if cardiogenic shock develops
Discontinue if ischaemic pain occurs shortly after starting therapy
Consider reducing initial dose in the elderly
Advise patient not to take St John's wort concurrently
Advise patient Seville (sour) orange products may increase plasma level
Grapefruit juice should not be taken simultaneously
Grapefruit prod increase dihydropyridine Ca channel blocker bioavailability
Advise patient of need for high oral hygiene standards
Mild gingival enlargement has been reported in patients with pronounced gingivitis/periodontitis. The enlargement can be avoided or reversed by careful oral hygiene.
Significant hypotension with subsequent tachycardia may result in some patients. In susceptible patients, this may escalate to myocardial ischaemia.
Felodipine is contraindicated during pregnancy.
Use of felodipine during pregnancy is contraindicated by the manufacturer. Animal studies have shown teratogenic effects. Human data is limited and as such a potential risk cannot be ruled out.
Felodipine is contraindicated during breastfeeding.
Abdominal pain
Aggravation of angina
Angioedema
Ankle oedema
Arthralgia
Constipation
Diarrhoea
Dizziness
Dyspnoea
Exanthema
Exfoliative dermatitis
Fatigue
Fever
Flushing
Gingival hyperplasia
Gingivitis
Gynaecomastia
Headache
Hepatic disorders
Hypersensitivity reactions
Hypotension
Impotence
Increases in hepatic enzymes
Leukocytoclastic vasculitis
Menorrhagia
Myalgia
Myocardial ischaemia
Nausea
Palpitations
Paraesthesia
Peripheral oedema
Photosensitivity
Pollakiuria
Pruritus
Rash
Restlessness
Sexual dysfunction
Sweating
Syncope
Tachycardia
Tinnitus
Tremor
Urinary frequency
Urticaria
Vomiting
Weight gain
The manufacturer does not recommend breastfeeding whilst taking felodipine. Available data indicates felodipine is expressed in human breast milk, but the quantity and the effects on exposed infants are unknown.