• celecoxib 100mg capsules
• celecoxib 200mg capsules
  

  Therapeutic Indications

  Uses

  Ankylosing spondylitis
  Symptomatic relief in the treatment of osteoarthritis
  Symptomatic relief in the treatment of rheumatoid arthritis

  Dosage

  • Adults
  • Patients with Hepatic Impairment

  Use for the shortest duration possible and lowest effective dose.

   

  Osteoarthritis:

  
  200 mg once daily or 100mg twice daily. Increase dose to 200 mg twice daily if needed to achieve symptom relief. If no additional therapeutic benefit seen after 2 weeks then consider other therapeutic options. Maximum daily dose: 400mg daily.

   

   

  Rheumatoid arthritis:

  
  100mg twice daily. Increase dose to 200 mg twice daily if needed to achieve symptom relief. If no additional therapeutic benefit seen after 2 weeks then consider other therapeutic options. Maximum daily dose: 400mg daily.

   

   

  Ankylosing spondylitis:

  
  200 mg once daily or 100mg twice daily. Increase dose to 400mg once daily or 200 mg twice daily if needed to achieve symptom relief. If no additional therapeutic benefit seen after 2 weeks then consider other therapeutic options. Maximum daily dose: 400mg daily.

  Contraindications

  Children under 18 years
  Females attempting to conceive
  Asthma, urticaria or acute rhinitis associated with NSAIDS
  Breastfeeding
  Cerebrovascular disorder
  Congestive cardiac failure
  Galactosaemia
  Gastrointestinal haemorrhage
  Inflammatory bowel disease
  Ischaemic heart disease
  Nasal polyps, angioedema, and bronchospastic reactivity to NSAIDs
  Peptic ulcer
  Peripheral arterial circulatory disorder
  Pregnancy
  Renal impairment - creatinine clearance below 30 ml/minute
  Severe hepatic impairment - Child-Pugh score greater than or equal to 10

  Precautions and Warnings

  Elderly
  Oedema
  Risk factors for cardiovascular disorder
  Tobacco smoking
  Alcoholism
  Cardiac impairment
  CYP2C9 poor metaboliser genotype
  Diabetes mellitus
  Glucose-galactose malabsorption syndrome
  Hepatic impairment
  History of cardiac failure
  History of gastrointestinal bleeding
  History of gastrointestinal disorder
  History of gastrointestinal ulceration
  Hyperlipidaemia
  Hypertension
  Hypovolaemia
  Lactose intolerance
  Reduced left ventricular function
  Renal impairment

  Pregnancy and Lactation

  Pregnancy

  Celecoxib is contraindicated in pregnancy.

  Lactation

  Celecoxib is contraindicated in breastfeeding.

Side Effects

Accidental injury
Acute labyrinthitis
Acute renal failure
Aggravated allergy
Allergic reaction
Alopecia
Anaemia
Anaphylaxis
Angina
Angioedema
Anosmia
Anxiety
Arrhythmias
Arthralgia
Aseptic meningitis
Ataxia
Blurred vision
Breast tenderness
Bronchopneumonia
Bronchospasm
Cardiac failure
Cerebral infarct
Chest pain
Confusion
Conjunctivitis
Cough
Deep vein thrombosis (DVT)
Depression
Dizziness
Dysphagia
Dysphonia
Dyspnoea
Ecchymosis
Electrolyte disturbances
Erythema multiforme
Exacerbation of epilepsy
Exfoliative dermatitis
Fatigue
Floaters
Flushing
Ganglion
Gastro-intestinal disturbances
Gastro-intestinal perforation
Gastro-intestinal ulceration
Haemorrhage
Hallucinations
Headache
Hearing disturbances
Hepatitis
Hyperkalaemia
Hypertension
Hypertonia
Hyponatraemia
Increase in blood urea nitrogen
Increase in creatinine
Increases in hepatic enzymes
Infections
Inflammatory bowel disease
Influenza-like symptoms
Insomnia
Interstitial nephritis
Jaundice
Leg cramps
Leucopenia
Lipoma
Liver function disturbances
Melaena
Menstrual disturbances
Myocardial infarction
Myositis
Nephrolithiasis
Nocturia
Oedema
Palpitations
Pancreatitis
Pancytopenia
Paraesthesia
Pharyngitis
Photosensitivity
Pneumonitis
Prostatic hyperplasia
Pulmonary embolism
Retinal artery occlusion
Retinal vein occlusion
Rhinitis
Severe hepatic reactions
Sinusitis
Skin disorder
Somnolence
Stevens-Johnson syndrome
Stomatitis
Suppressed female fertility
Tachycardia
Taste disturbances
Thrombocytopenia
Toxic epidermal necrolysis
Vasculitis
Vertebral and long bone fractures
Weight gain