Therapeutic Indications Uses Juvenile idiopathic arthritis Neoplastic disease Rheumatoid arthritis Severe psoriasis when other regimens unsuitable/ineffective Malignant diseases including trophoblastic neoplasm, acute leukaemias and non-Hodgkin's lymphoma. Severe forms of psoriasis including chronic plaque psoriasis, erythrodermic psoriasis, psoriatic arthritis and pustular psoriasis, when other regimens are unsuitable or ineffective. Active rheumatoid arthritis in adults. Juvenile idiopathic arthritis. Unlicensed Uses Autoimmune disease Crohn's disease - maintenance of remission The maintenance of remission of Crohn's disease. Treatment of autoimmune diseases, including juvenile dermatomyositis, vasculitis uveitis, systemic lupus erythematosus, localised scleroderma, and sarcoidosis.

Therapeutic Indications Uses Juvenile idiopathic arthritis Neoplastic disease Rheumatoid arthritis Severe psoriasis when other regimens unsuitable/ineffective Malignant diseases including trophoblastic neoplasm, acute leukaemias and non-Hodgkin's lymphoma. Severe forms of psoriasis including chronic plaque psoriasis, erythrodermic psoriasis, psoriatic arthritis and pustular psoriasis, when other regimens are unsuitable or ineffective. Active rheumatoid arthritis in adults. Juvenile idiopathic arthritis. Unlicensed Uses Autoimmune disease Crohn's disease - maintenance of remission The maintenance of remission of Crohn's disease. Treatment of autoimmune diseases, including juvenile dermatomyositis, vasculitis uveitis, systemic lupus erythematosus, localised scleroderma, and sarcoidosis.

Abdominal discomfort Abnormal tissue cell changes Acne Agranulocytosis Alopecia Anaemia Anaphylactic reaction Anorexia Aphasia Arthralgia Ataxia Azotaemia Bladder inflammation Bone marrow depression Chills Cirrhosis Confusion Conjunctivitis Convulsions Cystitis Diarrhoea Dizziness Drowsiness Enteritis Eosinophilia Epidermal necrolysis Exacerbation of psoriasis Eye irritation Fatigue Fever Gastro-intestinal symptoms Gingivitis Gynaecomastia Haematemesis Haematuria Haemorrhage Headache Hemiparesis Hepatic disorders Hepatic necrosis Hepatotoxicity Herpes zoster Hypogammaglobulinaemia Hypotension Immunosuppression Impaired fertility Impotence Increased susceptibility to infection Increases in hepatic enzymes Interstitial pneumonitis Leucopenia Leukoencephalopathy Loss of libido Lymphoma Malabsorption Malaise Melaena Menstrual disturbances Metabolic changes Mood changes Mucositis Myalgia Nausea Nephropathy Nervous system effects Neutropenia Oligospermia Opportunistic infections Osteoporosis Pancytopenia Paresis Pericardial effusion Pericarditis Pharyngitis Photosensitivity Pleural thickening Pleuritic pain Pneumonia Pneumonitis Precipitation of diabetes Psychiatric disorders Pulmonary fibrosis Pulmonary oedema Renal failure Respiratory disorders Sepsis Septicaemia Skin disorder Stevens-Johnson syndrome Stomatitis Telangiectasia Thrombocytopenia Thromboembolic disorders Toxic megacolon Urinary abnormalities Vascular disorders Vasculitis Visual disturbances Vulvovaginal disorders

Contraindications Infection Alcoholism Breastfeeding Immunodeficiency syndromes Pregnancy Severe haematological disorder Severe hepatic impairment Severe renal impairment Significant pleural effusion